So far, complex tissue cancer can only be diagnosed by using the antibodies method which will binds to the specific protein on the cancer cell’s surface. However, researches in Institute for Molecular Systems Biology at ETH Zurich and Julian Watts from the Institute of Systems Biology in Seattle (USA) had come out with the new method to develop better antibodies know as “Cell Surface-Capturing” (CSC).
According to the researcher’s leader, Bernd Wollscheid, this technique can identify a large number of proteins on the cell’s surface at certain time. The successful behind this method is, the researches use the fact that the protein’s surface is all glycoprotein in which then will broken into fragments by using an enzyme. Next, the protein’s fragments that attached to the sugar residue will then extracted by matching counterpart to the adaptor. Thus, these extracted fragments can be analysis for the mass and composition through the comparison with the protein databanks.
In short, through this new technology, different cell types or cancer forms and stages can be distinguished by looking at the differences in the quantity and type of the proteins on the cell’s surface.
By: 42111278
Reference:
http://www.sciencedaily.com/releases/2009/06/090606194216.htm
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